Index of Substances for Volumes II/4, II/6, II/14, and II/19

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The term "dispenser" means a practitioner who so delivers a controlled substance to an ultimate user or research subject. The term "distributor" means a person who so delivers a controlled substance or a listed chemical. As used in schedule I c , the term "isomer" means any optical, positional, or geometric isomer. As used in schedule II a 4 , the term "isomer" means any optical or geometric isomer. The term "manufacturer" means a person who manufactures a drug or other substance. Such term does not include the mature stalks of such plant, fiber produced from such stalks, oil or cake made from the seeds of such plant, any other compound, manufacture, salt, derivative, mixture, or preparation of such mature stalks except the resin extracted therefrom , fiber, oil, or cake, or the sterilized seed of such plant which is incapable of germination.

A Opium, opiates, derivatives of opium and opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible within the specific chemical designation. Such term does not include the isoquinoline alkaloids of opium.

C Coca leaves, except coca leaves and extracts of coca leaves from which cocaine, ecgonine, and derivatives of ecgonine or their salts have been removed. F Any compound, mixture, or preparation which contains any quantity of any of the substances referred to in subparagraphs A through E.

A which the Attorney General has found to be and by regulation designated as being the principal compound used, or produced primarily for use, in the manufacture of a controlled substance;. B which is an immediate chemical intermediary used or likely to be used in the manufacture of such controlled substance; and.

C the control of which is necessary to prevent, curtail, or limit the manufacture of such controlled substance. C protracted loss or impairment of the function of a bodily member, organ, or mental faculty. B The designation of gamma butyrolactone or any other chemical as a listed chemical pursuant to paragraph 34 or 35 does not preclude a finding pursuant to subparagraph A of this paragraph that the chemical is a controlled substance analogue.

Y Any salt, optical isomer, or salt of an optical isomer of the chemicals listed in subparagraphs M through U of this paragraph. E Repealed. A a distribution, receipt, sale, importation, or exportation of, or an international transaction involving shipment of, a listed chemical, or if the Attorney General establishes a threshold amount for a specific listed chemical, a threshold amount, including a cumulative threshold amount for multiple transactions as determined by the Attorney General, in consultation with the chemical industry and taking into consideration the quantities normally used for lawful purposes , of a listed chemical, except that such term does not include—.

I the Attorney General has determined under section of this title that the drug or group of drugs is being diverted to obtain the listed chemical for use in the illicit production of a controlled substance; and. II the quantity of the listed chemical contained in the drug included in the transaction or multiple transactions equals or exceeds the threshold established for that chemical by the Attorney General;.

B a distribution, importation, or exportation of a tableting machine or encapsulating machine.

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The substances excluded under this subparagraph may at any time be scheduled by the Attorney General in accordance with the authority and requirements of subsections a through c of section of this title. B i Except as provided in clause ii , such term does not include an anabolic steroid which is expressly intended for administration through implants to cattle or other nonhuman species and which has been approved by the Secretary of Health and Human Services for such administration.

C i Subject to clause ii , a drug or hormonal substance other than estrogens, progestins, corticosteroids, and dehydroepiandrosterone that is not listed in subparagraph A and is derived from, or has a chemical structure substantially similar to, 1 or more anabolic steroids listed in subparagraph A shall be considered to be an anabolic steroid for purposes of this chapter if—. I the drug or substance has been created or manufactured with the intent of producing a drug or other substance that either—. II the drug or substance has been, or is intended to be, marketed or otherwise promoted in any manner suggesting that consuming it will promote muscle growth or any other pharmacological effect similar to that of testosterone.

C bringing together a buyer and seller, a buyer and transporter, or a seller and transporter. Each reference in clause i to ephedrine, pseudoephedrine, or phenylpropanolamine includes each of the salts, optical isomers, and salts of optical isomers of such chemical. B Such term does not include a product described in subparagraph A if the product contains a chemical specified in such subparagraph that the Attorney General has under section a of this title added to any of the schedules under section c of this title. In the absence of such scheduling by the Attorney General, a chemical specified in such subparagraph may not be considered to be a controlled substance.

A means a person, entity, or Internet site, whether in the United States or abroad, that knowingly or intentionally delivers, distributes, or dispenses, or offers or attempts to deliver, distribute, or dispense, a controlled substance by means of the Internet; and. III registered under section f of this title in the State in which the patient is located, unless the practitioner—. AA an employee or contractor of the Department of Veterans Affairs who is acting in the scope of such employment or contract; and.

BB registered under section f of this title in any State or is utilizing the registration of a hospital or clinic operated by the Department of Veterans Affairs registered under section f of this title;. B is being conducted while the patient is being treated by, and in the physical presence of, a practitioner—. I is exempted from such registration in all States under section d of this title; or. D i is being conducted during a public health emergency declared by the Secretary under section d of title 42; and.

E is being conducted by a practitioner who has obtained from the Attorney General a special registration under section h of this title;. I that prevents the patient from being in the physical presence of a practitioner registered under section f of this title who is an employee or contractor of the Veterans Health Administration acting in the usual course of business and employment and within the scope of the official duties or contract of that employee or contractor;.

II that prevents the patient from being physically present at a hospital or clinic operated by the Department of Veterans Affairs registered under section f of this title;. III during which the primary care practitioner of the patient or a practitioner otherwise practicing telemedicine within the meaning of this paragraph is unable to provide care or consultation; and. IV that requires immediate intervention by a health care practitioner using controlled substances to prevent what the practitioner reasonably believes in good faith will be imminent and serious clinical consequences, such as further injury or death; and.

I is an employee or contractor of the Veterans Health Administration acting within the scope of that employment or contract;. II is registered under section f of this title in any State or is utilizing the registration of a hospital or clinic operated by the Department of Veterans Affairs registered under section f of this title; and. III issues a controlled substance prescription in this emergency context that is limited to a maximum of a 5-day supply which may not be extended or refilled; or. G is being conducted under any other circumstances that the Attorney General and the Secretary have jointly, by regulation, determined to be consistent with effective controls against diversion and otherwise consistent with the public health and safety.

A means the dispensing of a controlled substance in schedule III, IV, or V in accordance with refill instructions issued by a practitioner as part of a valid prescription that meets the requirements of subsections b and c of section of this title, as appropriate; and.

B does not include the issuance of a new prescription to an individual for a controlled substance that individual was previously prescribed. The warning device shall be used each time that a load is moved over a work station or a traffic area. Each worker must wear a safety harness secured by a fall arrest connecting device to an anchorage system in accordance with section This prohibition does not apply to conveyors designed specifically for moving people and used for such purpose, or to slow-moving conveyors to which workers may safely have access.

The resetting of the emergency stop device after it is used shall not by itself cause the start up of the machine, except if the conveyor is moving slowly and workers can have access to it safely. These panels shall be equipped with an interlocking device. The warning device shall be used in yards and in buildings when there are persons nearby and in areas presenting a risk, such as doors and around bends.

Subparagraph 2 of the first paragraph does not apply to tracked bulldozers and hauling machines.

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This section does not apply to a low profile agricultural tractor when it is used in an orchard. The design, manufacture or installation of a protective structure is deemed to be in compliance with the standard if it has been certified, signed and sealed by an engineer. This section does not apply to graders or loaders used for snow removal if these vehicles only circulate in places where there is no risk of overturning. Nor does it apply to a low profile agricultural tractor when used in an orchard.

The plate shall be permanently attached and the inscriptions thereupon shall be legible at all times. Assistants can help the shot-firer in his work, with the exception of setting off the blast which shall be done by the shot-firer himself. The shot-firer shall supervise and co-ordinate the work of his assistants. The Commission can also cancel or suspend, for a period of from 3 to 24 months, the certificate of a shot-firer when the work he does is the subject of a remedial order under section of the Act respecting occupational health and safety or of an order under section of that Act, by reason that he refused to comply with the Act or this Regulation.

The information referred to in subparagraph 1 of the first paragraph shall be collected by a qualified person. The precautionary measures referred to in subparagraph 2 of the first paragraph shall be drafted by a qualified person and implemented. If it proves impossible by ventilating the enclosed area to maintain an internal atmosphere in compliance with the standards provided under subparagraphs 1 and 3 of the first paragraph, a worker may only enter or be present in this area if he wears the respiratory protective equipment specified in section 45 and if the internal atmosphere of this enclosed area complies with subparagraph 2 of the first paragraph.

These measures include training devised by a qualified person and dealing with methods and techniques that shall be employed by the worker to carry out his work safely in this enclosed area. They can also provide, where necessary, for the use of equipment that is appropriate for this type of work as well as the other personal and collective protective means and equipment that the worker must use. The readings shall be taken in such a manner as to obtain an accuracy equivalent to that obtained following the methods described in section 44 or, when these measures cannot be applied, by following another recognized method.

However, in the case where the readings are made using continuous reading instruments equipped with alarms that sound when the air quality does not meet the standards set out in subparagraphs 1 to 3 of the first paragraph of section , the readings shall only be recorded in the register if the alarm goes off. Only those entries in the register that do not comply with the standards set out in subparagraphs 1 to 2 of the first paragraph of section shall be kept for a period of at least 5 years.

The person responsible for the supervision shall remain outside the enclosed area. Such a procedure shall be implemented as soon as any situation so requires. This procedure shall provide for the necessary rescue equipment. It may also make provision for a team of rescuers, an evacuation plan, alarm and communications devices, personal protective equipment, safety harnesses, lifelines, a first aid kit with emergency equipment as well as recovery equipment. In a scientific dive performed by a government agency, educational institution, non-profit research institution or any other non-profit institution, the employer must comply with the provisions of this Division or the Canadian Association for Underwater Science Standard of Practice for Scientific Diving, 3rd Edition, October Subject to sections In addition, the dive team includes 2 hyperbaric chamber operators when such a chamber is required.

Subparagraph 2 and the second paragraph also apply in the case of police diving. Section A scuba diver may not act as a standby diver for a surface-supplied diver. The duties performed on the surface in relation to diving operations must be assumed by workers who are not members of the dive team. An umbilical may be used as a lifeline if it was designed for that purpose. If not, a lifeline must be integrated to protect the umbilical against any tension. Except in case of emergency, a diver must never be in a situation of undue exposure defined in those tables.

The recording must be kept for at least 48 hours. A dive must be interrupted if the 2-way voice communication system should fail. When a diver is in the water, no boat or other floating equipment in the work area may be moved without the authorization of the diving supervisor. If it is impossible to use a deflector, another means ensuring equivalent safety must be approved by an engineer. Water supplying a heating or cooling unit must not come from a contaminated environment.

A diver must wear a wet suit under the diving suit in the cases referred to in subparagraphs 1 and 2 of the second paragraph. If the stage is a cage, submersible compression chamber, platform or diving bell, it must meet, in addition to the requirements referred to in the second paragraph, the requirements referred to in paragraph 3 of section 3.

The drawings of the means must be prepared by an engineer and available at the diving station. The crane, boom truck or device referred to in the first paragraph must be available at all times to move divers. The crane, boom truck or device may not be used for other purposes while divers are still in the water. Only dive team members may give instructions to the operator of the crane, boom truck or device referred to in the first paragraph. The employer must keep the maintenance record set up under Clause 6. Each component of the supply system must operate independently. An interruption of the main supply must not prevent supply from the auxiliary reserve or the emergency self-contained breathing apparatus.

The diving supervisor may also require that a diver again undergo the physical examination referred to in the first paragraph and obtain a new medical certificate, if the supervisor considers that the diver is unfit to dive safely. Before diving again, the diver must obtain a medical report attesting that the diver is fit to dive. They must be kept in good condition. Likewise, the measures apply if sediments containing contaminants are moved with equipment resulting in their suspension at the underwater workstation.

If the concentration level of contaminants may not be established before the dive, the preventive measures in a contaminated environment in sections The submersible compression chamber referred to in subparagraphs 2 and 3 must comply with CSA Standard Z The standby diver in the submersible compression chamber also acts as tender. The diving operation referred to in the first paragraph may be performed if the employer has agreed with the owner of a hydraulic structure or a hydroelectric plant that measures to control the flow of turbine discharge or discharged water must be planned and implemented before beginning the work and maintained until the work is completed in order to ensure stability in the current at the dive site.

A copy of the agreement must be available at the diving station. If the recipient has already contained such materials, no work involving welding, cutting or heating may be undertaken on the recipient until it has been properly cleaned in order to eliminate any material that is combustible or likely to discharge toxic or inflammable vapours when heated.

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Conduits and connections shall be disconnected, then closed to eliminate the spilling of any material that is combustible or likely to discharge toxic or inflammable vapours when heated. However, such grounding is not necessary if the tools, appliances or accessories connected to the auxiliary plugs are equipped with double insulation or a third conductor ensuring the continuity of the grounding, or if the branch circuits are protected by Class A ground fault circuit interrupters.

This section does not apply to automated cleaning systems. Administration of rosiglitazone greatly ameliorated hyperinsulinemia in diabetic patients and improved fasting and postprandial glucose levels Fig. In addition, rosiglitazone treatment also decreased low-density lipoprotein cholesterol, blood pressure, and HOMA IR index data not shown. Furthermore, administration of rosiglitazone resulted in a decrease in serum RBP4 level Serum insulin A , glycosylated hemoglobin HbA1c B , serum RBP4 C , and adiponectin D levels before and after treatment with rosiglitazone 4 mg daily for 6 months in newly diagnosed type 2 diabetic patients.

Statistical significance of differences is calculated by Wilcoxon signed rank test. Spearman correlation analysis was conducted in all subjects. RBP4, a recently discovered adipokine, was reported to cause insulin resistance and diabetes 6 , 7. It has been suggested that RBP4 interferes with insulin signaling in skeletal muscle and liver and thus results in hyperglycemia 6 , In the present study, we showed that the serum RBP4 level was higher in patients with diabetes than those without diabetes.

Because HOMA IR represents both hepatic and peripheral skeletal muscle and adipose tissue insulin resistance, we performed a euglycemic-hyperinsulinemic clamp study to determine the correlation between serum RBP4 and whole-body insulin sensitivity measured by GDR. It is conceivable that elevated RBP4 may alter insulin signaling in skeletal muscle and liver. Consequently, insulin-mediated glucose transporter GLUT4 translocation in muscle and gluconeogenic enzymes such as phosphoenolpyruvate carboxykinase PEPCK in the liver may be impaired in obese diabetic patients 6.

Future studies are needed to elucidate the molecular mechanisms by which RBP4 may interfere with insulin action in insulin-sensitive tissues. It is well known that obesity is strongly associated with insulin resistance. Recent advances in adipose biology have revealed that several adipokines may contribute to insulin resistance.

Studies have shown that serum RBP4 levels are associated with waist circumference 26 and correlated to the percent trunk fat rather than to the percent body fat In the present study, we reported that visceral obesity, not abdominal sc obesity, was linked to increased serum RBP4 levels because subjects with visceral obesity had higher serum RBP4 levels than those with nonvisceral obesity. Furthermore, we found that the serum adiponectin level was inversely correlated with the serum RBP4 level. This is consistent with previous studies that showed that the serum adiponectin level was reduced in obese subjects A lower serum adiponectin level may contribute to impaired glucose transport in skeletal muscle and excessive hepatic glucose production 28 , It appears that RBP4 and adiponectin are tightly regulated in response to weight gain, especially in the visceral adipose area.

Thiazolidinediones are established insulin sensitizers 30 , which have been widely prescribed to improve insulin sensitivity in patients with diabetes. We set out to test the hypothesis that thiazolidinedione treatment will result in a decrease in serum RBP4 level in patients with diabetes. Indeed, patients treated with rosiglitazone for 6 months showed a significant decrease in serum RBP4 levels and an increase in adiponectin levels, which were accompanied by improved insulin sensitivity.

Furthermore, we also observed rearrangement of body fat distribution with decreases of VFA and increases of SFA in response to rosiglitazone treatment.

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Consistent with a previous study 26 , our data showed that men had higher serum RBP4 concentration than that of women. The gender difference in RBP4 level, however, does not affect the relationship between serum RBP4 and most metabolic parameters measured in this study. The gender difference in adiponectin has also been reported previously In conclusion, serum RBP4 level is positively correlated with visceral adiposity in Chinese subjects with and without type 2 diabetes.

Subjects treated with rosiglitazone showed reduced visceral fat mass, decreased serum RBP4 levels, and improved insulin sensitivity.


However, additional work is warranted to determine whether increased serum RBP4 is the cause or the consequence of insulin resistance. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide.

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Oxford Academic. Google Scholar. Haiya Wu. Yuqian Bao. Chen Wang. Junxi Lu. Jiehua Zhu. Kunsan Xiang. Cite Citation. Permissions Icon Permissions. Abstract Objective: Previous studies have shown that adipose-derived serum retinol-binding protein 4 RBP4 levels are increased in insulin-resistant mouse models and in subjects with insulin resistance or type 2 diabetes.